The Yang Lab of Computational and Systems Biology at Rutgers University studies how cellular states and interactions shape human disease and therapeutic response. We combine single-cell and spatial multi-omics, quantitative modeling, and experimental approaches to uncover mechanisms and identify new opportunities for therapeutic intervention.

What We Do

Decode Immune Cell States

Regulatory programs and engineering of dendritic cell and astrocyte.

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Map Spatial Ecosystems

Cellular neighborhoods and interactions in cancer and neurodegeneration.

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Build Quantitative Models

Computational methods for high-resolution and dynamic tissue biology.

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Featured Research

mregDCs & Immunotherapy

Spatial Transcriptomics

DS/AD Multi-Omics